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however, the concentration of water-soluble nutrients, such as vitamin C and vitamin B 9 (folate), while still present in good amounts, gets reduced when the leaves are exposed to heat

In several RCTs, GLP-1RAs, when used alone or in combination with other hypoglycemic agents including metformin, sulfonylurea, DPP-4 inhibitor, thiazolidinedione, and sodium-glucose cotransporter 2 inhibitor, showed superior or non-inferior blood glucose lowering ability compared to insulin treatment [64,65]

Acknowledgments The work in this study was supported by the Natural Science Foundation of China (grants 30971188, 81273279, 81302560, and 81373201)

Targeted metabolomics analysis shows that 5FU treatment promotes significant changes in metabolite abundance over time (Fig