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As a result, fragmented urban fabrics emerged, characterized by discontinuous and poorly functional landscapes, contributing to the proliferation of so-called wastelands

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In this context, designing and constructing integrated nanoplatforms that combine RT, phototherapy, or sonodynamic therapy (SDT) with the ability to actively remodel the TME, efficiently induce ICD, and enable smart delivery of immunomodulators has emerged as a highly promising research direction (104109)

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