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Antioxidant Response Elements: Discovery, Classes, Regulation and Potential Applications

HDL from ischemic cardiomyopathy and CAD subjects also have reduced cholesterol efflux acceptance capacity, which likely leads to increased foam cell formation in the atherosclerotic lesion and increased atherogenesis (746,863)

in tandem with other human factors such as the human leukocyte antigen (HLA), epigenetics, preexisting comorbidities (i.e., T2DM, CVD, obesity), age, preceding systemic impairments (i.e., hyperinflammation, micro-thrombosis, fibrosis, dysbiosis, autoimmunity, etc.), and socio-demographic factors (i.e., food security, environment, access to medical care) 22,27,28

10.1039/B9PY00216B Polym