Liu et al., 2014), a novel dimeric form of the K1 domain, designated K1K1 (Vallarola et al., 2020), the semi-synthetic engineered K1 domain, designed to be multimer by biotin-avidin interaction (Simonneau et al., 2015), a MET-agonistic DNA aptamer (Ueki et al., 2016, 2020), and MET-agonistic synthetic macrocyclic peptides (Sato et al., 2020)
Serum and Cerebrospinal Fluid Concentrations of Homoarginine, Arginine, Asymmetric and Symmetric Dimethylarginine, Nitrite and Nitrate in Patients With Multiple Sclerosis and Neuromyelitis Optica
Interestingly, co-administration of KL1 improved survival rates by 2-fold ( P 12 across 2 experiments), suggesting potential therapeutic activity (Fig
Because one is studied for protection and signalling and the other for migration and vascularisation, researchers frequently run them together