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In vivo studies Effect of BER chitosomes and BER solution on motor activity, coordination, and balance in rat model of parkinsonism The degeneration of dopaminergic neurons is responsible for motor dysfunction in PD patients [92]

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Furthermore, ZLN005 treatment activates mitophagy, as manifested by increased expression of LC3-II and co-localization between LC3 and mitochondria, and the protective effects are abrogated in TFEB-knockdown cells, suggesting that PGC-1 activation improves mitochondrial dysfunction via TFEB-mediated autophagy