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The American Diabetes Association recommends regular screening for DPN at the time of diabetes diagnosis in type 2 diabetes (T2D) and 5 years after diagnosis in type 1 diabetes (T1D) and annually thereafter

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Similarly, metabolites potentially derived from gut microbiota were reported to be associated with renal and cerebrovascular endothelial, podocyte, and proximal tubule damage in early diabetic kidney disease in diabetes Mellitus patients (Balint et al., 2023b)