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Last updated April 2026 Sources verified against the Mounjaro FDA prescribing information, NEJM SURPASS-2, a 2026 review in Anais Brasileiros de Dermatologia, and the American Academy of Allergy, Asthma & Immunology

These include some heartburn medicines, including esomeprazole (Nexium), famotidine (Pepcid AC), lansoprazole (Prevacid), omeprazole (Prilosec OTC), pantoprazole (Protonix), rabeprazole (Aciphex), as well as some diabetes, gout, and chemotherapy drugs

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binds GLP-1 receptors on pancreatic -cells (stimulating glucose-dependent insulin secretion), -cells (suppressing glucagon), gastrointestinal tract (slowing gastric emptying), and hypothalamic neurons (suppressing appetite and food intake via arcuate nucleus signaling)