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After coronary artery ligation in mice, intraperitoneal T4 treatment upregulated cardiac ILK and Akt activity, enhanced early myocyte survival, and improved cardiac function establishing the mechanistic basis for the broader tissue-repair claims associated with thymosin beta-4 and its 1723 fragment TB-500

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doi: 10.1016/j.preteyeres.2020.100863

Previous publications demonstrated the effectiveness of intramuscular (IM) MTX at a dose of 25 mg/week for 12 months in a randomized controlled trial including thiopurine-nave patients with Crohns disease (Feagan et al