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Peptide Therapy Side Effects and Safety Profile: What 2025 Research Shows Common Peptide Therapy Side Effects (Generally Mild): Injection site reactions: redness, swelling, bruising (affects 15-30% of users) Temporary nausea or headaches (first 1-2 weeks) Increased appetite with growth hormone peptides Fluid retention in hands/feet (rare, resolves with dosage adjustment) Fatigue during initial adaptation phase Who Should Avoid Peptide Therapy: Pregnant or breastfeeding women (insufficient safety data) Active cancer patients (growth-promoting peptides may stimulate cell proliferation) Severe kidney or liver disease without medical clearance Anyone without qualified physician supervision FDA Approved vs