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( C and D ) C57BL/6 mice were subjected to daily i.p

Natural products frequently encounter substantial obstacles, including low bioavailability, limited penetration across the BBB, and inconsistent clinical trial outcomes, as exemplified by studies involving curcumin

Without treatment, the disease can be fatal

30 Manufacturers have used various substances to provide this protective barrierusually some type of starch, gelatin or lipid matrix that is combined with several other excipients, chemicals, or it may require substantial processing like hydrogenation