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The simplest way to understand the difference is this: tirzepatide is a dual agonist, while retatrutide is a triple agonist

In fact, MOTS-c levels naturally rise during exercise, and giving MOTS-c to mice has been shown to enhance their physical performance (they can run longer on a treadmill)

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Tirzepatide is injected under the skin (subcutaneously) using a pre-filled single-dose pen, a multi-dose KwikPen (for single patient use), and a single-dose vial with a syringe