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Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation

This breakdown covers both therapies from a clinical perspective so you can have an informed conversation with your provider

87 Coric et al have reported that individuals carrying a combination of the GSTM1-null genotype, active GSTT1, low-activity GSTA1, and variant GSTP1 genotypes exhibited a nine-fold increased risk for renal cell carcinoma compared with those with a reference genotype combination

It may also be prescribed when oral supplementation is not possible or not sufficient, for example after certain gastrointestinal surgeries or in severe malabsorption