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Administration of 300 mg/kg of APAP led to 100% mortality within 6 h, but 1,000 mg/kg of natsumikan extract and silymarin prolonged survival rates to 33.3% and 50.0%, respectively

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induces a decrease of hepatic GSH." So alcohol consumption leads to a depletion of glutathione levels in the liver where, ironically, glutathione is made and can lead to liver damage

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