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A: Anecdotal reports vary, with some noticing changes in a week, while others may need several weeks depending on dosage and condition

Compared to LLD, serotonergic deficits (lower serotonin transporter and 5-HT1A and 5-HT2A receptors) are greater and more widespread than in neurodegenerative diseases, including MCI, AD and PD and even greater in patients with AD and PD and comorbid depression [118,119,120,121]