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The absence of a prescribing clinician means there is no safety monitoring, no dose adjustment based on response, and no management plan if complications arise

SIBO Small intestinal bacterial overgrowth (SIBO), in particular methane dominant SIBO, sometimes called intestinal methanogen overgrowth (IMO), contributes to constipation by interfering with normal digestion and gut motility

CATEGORY 2 SUBSTANCES: Many peptides have been classified by the FDA as Category 2 bulk drug substances under Section 503A, designated as substances that may present significant safety risks

12 People with MTHFR genetic variants are often low in both folate and B12 due to impaired methylation