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Importantly, the pathophysiological consequences of elevated NET components in the follicular microenvironment are supported by parallel evidence: multiple studies link increased oxidative stress and inflammatory mediators in follicular fluid to reduced oocyte competence, lower fertilization rates, and poorer embryo quality in women with PCOS, providing a biologically plausible pathway by which NET-derived DNA, histones, and proteases could impair gamete quality and fertilization success [55]

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When MSM was combined with Vit C, the three enzymatic activities were restored reaching normal values (before starting competition)

It works as part of a larger antioxidant network, helping vitamins like E and C remain active in your system for longer periods