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NO modulates mitochondrial biogenesis also during myocytes differentiation by S-nitrosylation-mediated activation of the transcription factor CREB (cAMP response element-binding protein), which efficiently binds to the PGC-1a gene promoter region increasing its concentration and downstream signaling events [76]

Modified rotenone PD models using a low dose and chronic administration have shown promising outcomes with selective nigrostriatal neurodegeneration and positive aggregation of -synuclein cytoplasmic inclusions (Betarbet et al., 2003

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