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In the acute phase of ischemia, which is characterized by anoxic depolarization and a massive increase in [Ca 2+ ] i mediated by both Ca 2+ influx and Ca 2+ -induced Ca 2+ release from intracellular stores, the vesicular release from presynaptic terminals further adds to the glutamate elevation

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The second strategy entails the utilization of inhibitors targeting glucose transporter proteins or glutaminase in the treatment of tumors overexpressing SLC7A11

Given the above evidence, the multitarget properties of TCM formulations confer distinct benefits in modulating immune homeostasis, as summarized in Table 7