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The forced elimination of entire food groups rich in carbohydrates and other components can lead to deficiencies in nutrients such as protein, thiamine, folic acid, vitamin A, vitamin E, vitamin B6, calcium, magnesium, iron, and vitamin K [203]

Studies have shown that in the absence of GPX4, the calcium-independent phospholipase iPLA2 acts as a major ferroptosis suppressor in a GPX4-independent manner (Chen et al

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Importantly, the intraosseous delivery of AAV-delivered Chac2 shRNA in db/db mice with periodontitis markedly reduced neutrophil-aggravated systemic inflammatory comorbidity symptoms and improved glycemic control, underscoring the functional relevance of this pathway in diabetic comorbidity