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Promising treatments targeting the IFN- chemokine axis, JAK-STAT pathway, and Nrf2-ARE pathway, have recently emerged ( Figure 2 )

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Although the anti-Met macrocycles described above might be incapable of inducing dimerization, we reasoned that they might be rendered chemically amenable to induction of dimerization via an appropriate cross-linker (Fig

To date, the role of trained immunity has been increasingly recognized in SLE, allergic diseases, ASCVD, and MS