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RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

For assistance in Tanzania, we also thank Robert Fyumagwa, Annie Francis, Ernest Eblate Mjingo, Maulid Luziga and Grant Hopcraft

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Acknowledgements We acknowledge the contribution of Drs Abdullah Al-Tairar, Reem Al-Sabah, and Lemia Shaban in data collection in the original project (WF02/13)