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Advances in Therapy, 39 (6), 2452-2467

These mechanisms do not act independently but form an integrated regulatory network, with SIRT1 positioned centrally within the metabolismimmuneorgan axis. In processes including energy sensing, transcriptional control, redox balance, and cell fate determination, SIRT1 consistently occupies a central or upstream role in signal coordination, capable of orchestrating multiple pathways

Participants with long COVID, with symptom persistence over 12 weeks from infection, were also recruited