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Practical points (dose-related) Do not give IV use SC, IM or oral routes

1 Introduction Multiple sclerosis (MS), an immunoinflammatory disease, is caused by the chronic demyelination of nerve axons and, thus, disrupts the function of the central nervous system (CNS), eventually leading to severe disability, such as autonomic dysfunction, paralysis, disability of motor control, and cognitive impairment of the brain (www.atlasofms.org), which is compiled and updated by the Multiple Sclerosis International Federation (MSIF), it is estimated that 2.8 million people are affected by MS worldwide

Methods: The streptozotocin (STZ)-induced diabetic mice, and high glucose (HG)-treated human renal mesangial cells (HRMCs) were used to investigate the effect of HU on DKD

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