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[11] Structure [edit] Mammalian GPX1, GPX2, GPX3, and GPX4 (this protein) have been shown to be selenium-containing enzymes, whereas GPX6 is a selenoprotein in humans with cysteine-containing homologues in rodents

The uncontrolled generation of GSSG during oxidative stress can contribute to mitochondrial dysfunction by glutathionylation of target proteins, as described below

In sepsis-induced lung injury, H3K18la induces ferroptosis by upregulating RNA methylation levels of ACSL4 via promotion of Methyltransferase Like 3 (METTL3 ) expression 28

Better liver detoxification: Glutathione binds heavy metals, alcohol byproducts, and acetaminophen residues