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8 It may also help bones heal faster by improving blood supply and cellular activity at the site of the fracture

Data availability All data supporting the findings of this study are available from the corresponding authors on reasonable request

Upregulation of IGF-1R-dependent signaling in chondrocytes lacking IR The observation of increased chondrocyte numbers in growth plates from the mice lacking IR suggested the possibility of compensatory upregulation of IGF production and signaling, a similar phenomenon previously observed in osteoblasts lacking IGF-1R 12

Blood-gas analysis showed metabolic acidosis and a blood-ammonia level of 85.4 mol/L (1872 mol/L)