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doi: 10.3389/fimmu.2022.945129 109 PiaoXZhouJXueL

In experimental models, researchers may explore processes such as receptor-mediated signaling, pulsatile hormone release dynamics, and downstream metabolic pathway modulation

The more intense the activity is (think a 100-meter sprint or a 5-rep max set of squats), the more quickly you burn through the available ATP, which leads to fatigue