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J Thyroid Res (2013) 2013:424163

Although inflammation can be a protective response, sustained activation of neuroinflammatory pathways leads to neuronal injury and causes the progression of neurodegenerative disorders ( 2.5 Impaired protein degradation systems Dysfunction in systems responsible for protein degradation, such as the ubiquitin-proteasome system (UPS) and autophagy, contributes to the development of AD and PD