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Methods A comprehensive literature review was conducted using reputable databases, including PubMed, Scopus, Web of Science, and ScienceDirect

In preclinical models this dual mechanism produced greater weight loss than a maximal semaglutide dose, and in a Phase 2 diabetes trial higher survodutide doses reduced weight more than semaglutide though human superiority has not been formally established in head-to-head registration trials

In the present study, optimal concentrations of NMs enhanced enzyme activities

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