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doi:10.1371/journal.pone.0162590.g010 Diclofenac, L-NAME, L-Arginine and BPC 157 in Short-Bowel Rats PLOS ONE | DOI:10.1371/journal.pone.0162590 September 14, 2016 14 / 18 Finally, the differential beneficial effects of BPC 157 (COX and NOS blockade), L-arginine (NOS-blockade), and L-arginine-independent BPC 157 effects, might support the proposition that BPC 157 and L-arginine may act via two separate NO system pathways as previously sug- gested [3]

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This mechanism has been proposed to underlie observations related to tissue matrix integrity noted across multiple research studies