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GHK plasma levels naturally decline from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60, and microinfusion replenishes that depletion directly at the dermal layer

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On the basis of these studies, the capacity of HGF to modulate neuro-inflammation is thus associated with an alteration in the balance of pro-inflammatory (Th1 and Th17) and anti-inflammatory (Th2 and Tregs) CD4 + T cells by influencing dendritic cell function

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