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Nitric oxide deficiency in mitochondrial disorders: The utility of arginine and citrulline

6 Discussion Synthesizing the foregoing evidence, this article proposes a central hypothesis of ferroptosis in periodontitis: ferroptosis is not merely a passive accompaniment to disease progression, but has the potential to evolve into an important node and signal amplification link within the pathological network

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Excess alcohol and medications Regular alcohol intake and certain drugs force the liver to work harder, using up large amounts of glutathione to break down toxins, eventually lowering its available levels