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When glutathione levels fall: Liver cells become more vulnerable to injury Oxidative stress increases Detoxification of toxins and hormones becomes impaired The margin between a therapeutic dose and a toxic dose of acetaminophen is narrow

This leads us to our next critical topic

Notably, there was an abundance of increase in antioxidant genes such as CYP1A1, and several heatshock family protein members indicative of a stress response

This pattern suggests that MMN enhancement may precede changes to indices of clinical severity, highlighting the possible utility AEPs as a biomarker of treatment efficacy