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As mentioned above, abnormally accumulated proteins on the mitochondrial surface and in the TOM channel are eliminated, while proteins within the matrix are processed via the UPR mt pathway (Fig

Abstract Drug-resistant microbes are evolving as a result of the overuse of antibiotics in recent years leading to an increase in the prevalence of drug-resistant infections

Chronic neural inflammation and central nervous system (CNS) injury can also increase blood brain barrier permeability, allowing immune cells such as macrophages to migrate into the CNS from the bloodstream (Minogue, 2017)

Phase II clinical trials for inflammatory bowel disease reported no toxicity or adverse events in treated patients, though detailed safety data from these trials have not been published in peer-reviewed literature