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Our data showed that increased oxidative stress and mitochondrial dysfunction were involved in the pathogenesis of Fabry disease and were not fully eliminated even with ERT

A concentration of neurotransmitter serotonin, of which the disturbance in the early development plays a critical role in the establishment of innate anxiety, was increased in the prefrontal cortex of 3MST knockout mice 48

Tumor-induced immunosuppression, heterogeneous tumor microenvironments, and inefficient delivery of therapeutic agents often limit response rates and durability of treatment

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