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Warning Signs of Overdose A person who is on the verge of an overdose on depressants may not realize the severity of what is happening despite the many warning signs, which include the following: Extreme drowsiness Slipping in and out of consciousness Nausea Vomiting Slowed or labored breathing Cold, clammy skin A bluish tint to hands and feet Slow and/or weak pulse When a substance is consumed orally, such as a pill or alcohol, it is first filtered through the liver and stomach before it travels through the bloodstream and into the brain