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The morphological responses can be assessed by light and electron microscopy and immunohistochemistry and should be interpreted in conjunction with clinical pathology alterations (Ennulat et al

This Review discusses the functional inter-relationships between erythropoietin, iron and inflammatory mediators under physiologic conditions and in relation to the pathogenesis of renal anaemia, as well as recent insights into the molecular and cellular basis of erythropoietin production in the kidney

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If we are to achieve this ambitious objective, we will first need to identify valuable biological markers and to develop imaging techniques of better predictive value