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High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients.Br J Clin Pharmacol

These considerations are crucial to ensuring that peptide therapy is safe and effective for patients

For the mass spectrometry, the data-dependent MS 2 scan conditions were applied in both positive and negative mode: the scan range was from m/z 2501500, resolution was 60,000 for MS, and 30,000 for DDMS 2 (top 10), and the AGC target was 3E 6 for full MS and 1E 5 for DDMS 2 , allowing ions to accumulate for up to 200 ms for MS and 50 ms for MS/MS

It is widely accepted that the initial wave of C-fiber activity in phase 1 leads to phase 2, which depends on the inflammatory response and central sensitization