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Hydroxypyridones are able to release iron ions from biologically important structures (e.g., lactoferrin) (Halliwell and Gutteridge, 2015), potentially leading to the production of free radicals

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These include host-related factors (e.g., immune response and cytokine profile), immuno-factors, drug pharmacokinetics (e.g., metabolism and adherence to treatment), and parasite-specific factors, such as genetic plasticity and co-infections (Figure 1)

Owing to diverse TME including as perfusion, oxygenation, vascular irregularities, and other metabolic conditions, such stimuli-responsive systems are specially developed for anti-cancer medication [299]