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In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Gherasim et al., 2013), the most common B12 form in both food and human plasma (Obeid et al., 2015)

In transmethylation, the conversion of homocysteine to methionine is catalyzed by the enzyme methionine synthase, a vitamin B12-dependent zinc protein (Figure 3)

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Pernicious anemia is a type of vitamin B12 deficiency anemia, characterized by the bodys inability to absorb vitamin B12 efficiently