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My cat has anemia and IBD issues, so he needs it

Interestingly, TNF-alpha has been shown to interrupt tight junctions, thus worsening any underlying tight junction dysfunction

Cause of Low B12 levels Pernicious anaemia vegan diet malabsorption syndromes coeliac sprue Crohn's ulcerative colitis (UC) "food-bound cobalamin malabsorption syndrome" predisposing factors include atrophic gastritis, long term proton pump inhibitor or H2 antagnoist use, chronic alcoholism, gastrectomy/gastric bypass surgery, pancreatic exocrine failure, AIDS myeloma (paraprotein related assay interference) pregnancy combined oral contraceptive pill/HRT pancreatric insufficiency metformin, acute phase situations

The references below are starting points for the mechanisms discussed here