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Thus, the phosphorylation and nuclear localization of IRF3 were inhibited, ultimately suppressing the autoimmunity and ameliorating inflammatory arthritis ( 3.5 cGAS-STING signaling: RA onset and chronic inflammation According to the existing literature, it seems that cGAS-STING signaling predominantly contributes to the chronic inflammation in RA

trimethylamine is efficiently absorbed and metabolized to trimethylamine- N -oxide, which is excreted in the urine (13)

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Sattler M, Reddy MM, Hasina R, Gangadhar T, Salgia R