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The grey bar represents the 30% level of functional hepatocytes below which liver failure is thought to occur [38]

Yet, in the body, (1) -tocopherol is preferentially retained in the liver by the binding to -tocopherol transfer protein (-TTP), which incorporates -tocopherol into lipoproteins for delivery to extrahepatic tissues

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Active Akt phosphorylates multiple targets including Bad (preventing it from inhibiting anti-apoptotic Bcl-2), MDM2 (stabilizing p53), FOXO transcription factors (preventing pro-apoptotic gene expression), mTOR (promoting protein synthesis)