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The second hypothesis also involves redox reactions from the major methylated pyrrolopyrazine thione (structure 4, Figure 9) in the presence of oxygen, contributing to a flux of reactive oxygen species [61,62]

Despite methodological differences across studies, including inclusion criterion, sample collection, disease status, or additional confounders, contributing to divergent microbial profiles, the evidence of microbial dysbiosis in PD is consistent (Romano et al., 2021

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A high degree of polymorphisms within the gene encoding an NTHi haemoglobin-binding protein has been reported, which alters the protein affinity for iron capture/usage (Whitby et al., 2009)