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De novo assembly of Illumina reads, combined with guided assemblies using PacBio sequences, was applied for a final assembly yielding the human SFB genome sequence of Human-SFB-ML-1 in 13 contigs and Human-SFB-ML-2 in 11 contigs (Supplementary Table 1b)

In order to understand the inhibitory mechanism, the binding mode of -thujaplicin was predicted using homology model of hTYR

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Copper has a complex role in oxidative biology participating in both prooxidant chemistry (where free or weakly bound copper can catalyze damaging reactive-oxygen-species generation) and antioxidant chemistry (as the cofactor of Cu/Zn superoxide dismutase)