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However, systemic administration for pathologies local to the inner ear increases the likelihood of systemic toxicities and adverse side effects and creates a non-productive distribution of drug in which high levels of drug are found in the serum and correspondingly lower levels are found at the inner ear

These reversible post-translational modifications are the net result of the opposing activities of two sets of cellular enzymes: protein kinases and protein phosphatases

These early indicators help confirm biological activity while hair-specific results develop more slowly

Ongoing bloodwork is essential to monitor hormone levels, red blood cell counts, and overall safety markers