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While clinical evidence remains limited, both peptides may have potential applications in supporting chondrocyte viability and potentially attenuating cartilage degradation processes associated with osteoarthritic conditions

KPV represents a tripeptide fragment derived from the C-terminal region of alpha-melanocyte stimulating hormone (-MSH), consisting of the amino acid sequence lysine-proline-valine with molecular formula C16H30N4O4 and molecular weight of 342.43 g/mol

In a healthy system, the direct pathway facilitates movement via D1 receptor-mediated excitation, while the indirect pathway inhibits movement through D2 receptor-mediated suppression