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Corneal confocal microscopy offers a noninvasive alternative for tracking small fiber changes over time

Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden

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Palliative treatment can be implemented in healthcare within a foreseeable time