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Systemic inflammation rises

The American College of Rheumatology (ACR) initially suggested the 1990 diagnostic criteria based on the assessment of generalized pain defined as pain present on both sides of the body at upper and lower waist levels, in addition to axial skeletal pain, and on the assessment of pain sensitivity to palpation in more than 11 of the 18 established tender points, excluding the rest of the symptoms also present in this condition [77]

By the 2010s, athletes adopted it for its tissue-repairing effects, supported by preclinical data

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