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However, if these vasodilators enter the systemic circulation, they could contribute to ME/CFS symptoms such as fatigue, flu-like symptoms, pain, fever, and sleep disturbances, similar to the effects observed when vasodilators spill over in dysmenorrhea (346)

Vargas Valls, MD, MS Questions and Answers 467 Edited by Seth R

The peptide also promotes tissue remodeling by regulating matrix metalloproteinases, ensuring damaged collagen is removed while new, healthy collagen is formed

Some practitioners prefer it because of this, arguing that patients with certain metabolic variants may convert cyanocobalamin less efficiently