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The results indicated that the extract increased the production of insulin receptor substrate-1, inhibited phosphoinositol-dependent kinase-1 and protein kinase B, but enhanced glucose transporter 4 activity, thus increasing glucose absorption

TLR4 and NFB levels, which were high in PTZ group were also reduced on treatment with Rhein, which also reversed the upregulation of the IKB protein which is an activator of NFB 55

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At 6 weeks of age, mice were housed in plastic cages and received standard chow (AIN-76) and water ad libitum prior to experiment maintained on a 12 h/12 h light/dark cycle